Jean Sévigny Selected Research

Dextrans (Dextran)

1/2022	NTPDase8 protects mice from intestinal inflammation by limiting P2Y6 receptor activation: identification of a new pathway of inflammation for the potential treatment of IBD.
10/2019	Concentrates of two subsets of extracellular vesicles from cow's milk modulate symptoms and inflammation in experimental colitis.
9/2017	Expression of Ecto-nucleoside Triphosphate Diphosphohydrolases-2 and -3 in the Enteric Nervous System Affects Inflammation in Experimental Colitis and Crohn's Disease.

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Jean Sévigny Research Topics

Disease

39	Neoplasms (Cancer) 10/2023 - 08/2008
23	Inflammation (Inflammations) 07/2023 - 04/2002
8	Glioma (Gliomas) 01/2023 - 06/2012
7	Thrombosis (Thrombus) 07/2023 - 04/2002
5	Colitis 11/2022 - 09/2017
4	Hypertension (High Blood Pressure) 11/2023 - 01/2018
4	Osteoarthritis 08/2022 - 09/2013
4	Glioblastoma (Glioblastoma Multiforme) 07/2021 - 01/2016
4	Type 2 Diabetes Mellitus (MODY) 12/2020 - 06/2014
3	Urinary Bladder Neoplasms (Bladder Cancer) 10/2023 - 09/2014
3	Wounds and Injuries (Trauma) 09/2023 - 11/2022
3	Infections 01/2023 - 01/2019
3	Chondrocalcinosis (Pseudogout) 08/2022 - 06/2014
3	Fibrosis (Cirrhosis) 01/2020 - 11/2004
3	Aortic Valve Disease 12/2019 - 08/2015
3	Body Weight (Weight, Body) 05/2014 - 08/2007
2	Vascular System Injuries 11/2023 - 03/2004
2	Asthma (Bronchial Asthma) 11/2022 - 04/2010
2	Neoplasm Metastasis (Metastasis) 01/2022 - 01/2021
2	Sepsis (Septicemia) 12/2021 - 01/2019
2	Adenomyosis 04/2021 - 01/2019
2	Pain (Aches) 01/2020 - 11/2019
2	Vascular Calcification 01/2018 - 01/2017
2	Liver Cirrhosis (Hepatic Cirrhosis) 01/2018 - 05/2016
2	Crohn Disease (Crohn's Disease) 09/2017 - 10/2009
2	Gliosis 12/2016 - 11/2015
2	Glaucoma 05/2015 - 04/2010
2	Ganglion Cysts (Ganglion) 01/2014 - 04/2009
2	Colonic Neoplasms (Colon Cancer) 12/2010 - 10/2009
2	Biliary Liver Cirrhosis (Primary Biliary Cirrhosis) 03/2008 - 11/2004
1	Burns 11/2022
1	Astrocytoma (Pilocytic Astrocytoma) 11/2022
1	Cancer Pain 11/2022
1	Rupture 10/2022
1	Uterine Cervical Neoplasms (Cancer of the Cervix) 08/2022
1	Breast Neoplasms (Breast Cancer) 08/2022
1	Hypersensitivity (Allergy) 08/2022
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2022
1	Rheumatoid Arthritis 01/2022
1	Experimental Arthritis 01/2022
1	Arthritis (Polyarthritis) 01/2022
1	Melanoma (Melanoma, Malignant) 01/2022
1	Triple Negative Breast Neoplasms 01/2022
1	Hepatocellular Carcinoma (Hepatoma) 12/2021

Drug/Important Bio-Agent (IBA)

23	Adenosine Triphosphate (ATP)IBA 11/2023 - 04/2002
23	Adenosine (Adenocard)FDA LinkGeneric 11/2023 - 03/2004
18	ectoATPaseIBA 01/2023 - 11/2004
15	NucleotidesIBA 09/2023 - 04/2002
14	EnzymesIBA 10/2023 - 01/2015
12	5'-Nucleotidase (5' Nucleotidase)IBA 10/2023 - 11/2012
11	CD39 antigenIBA 01/2023 - 04/2009
11	NucleosidesIBA 01/2021 - 04/2002
10	triphosphoric acid (triphosphate)IBA 04/2021 - 04/2002
6	Adenosine Diphosphate (ADP)IBA 11/2023 - 04/2002
4	Adenosine Monophosphate (AMP)IBA 01/2022 - 01/2016
4	LipopolysaccharidesIBA 12/2021 - 08/2007
4	Proteins (Proteins, Gene)FDA Link 04/2020 - 01/2017
4	Biomarkers (Surrogate Marker)IBA 01/2019 - 06/2013
3	purineIBA 10/2023 - 01/2016
3	purinoceptor P2Y6IBA 11/2022 - 01/2015
3	Dextrans (Dextran)FDA Link 01/2022 - 09/2017
3	IsoenzymesIBA 05/2021 - 01/2018
3	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 12/2020 - 06/2014
3	Interleukin-8 (Interleukin 8)IBA 10/2019 - 01/2014
3	Apyrase (ATP Diphosphatase)IBA 09/2017 - 03/2004
2	beta-apocarotenoid-14',13'-dioxygenase (ADO)IBA 10/2023 - 05/2019
2	2,6- dichloro- 9- (1- (p- nitrobenzenesulfonyl)- 1,2,3,5- tetrahydro- 4,1- benzoxazepin- 3- yl)- 9H- purineIBA 10/2023 - 07/2021
2	PyrophosphatasesIBA 01/2023 - 08/2015
2	Cytotoxins (Cytolysins)IBA 08/2022 - 01/2013
2	sodium sulfate (sodium bisulfate)FDA LinkGeneric 01/2022 - 10/2019
2	Purinergic Receptors (Receptors, Purine)IBA 01/2022 - 05/2015
2	Interleukin-6 (Interleukin 6)IBA 12/2021 - 03/2008
2	Methotrexate (Mexate)FDA LinkGeneric 01/2021 - 01/2016
2	nucleotide pyrophosphataseIBA 12/2020 - 06/2014
2	CollagenIBA 01/2020 - 01/2018
2	SaltsIBA 11/2018 - 01/2018
2	Alkaline PhosphataseIBA 01/2018 - 01/2018
2	3,5- diethoxycarbonyl- 1,4- dihydrocollidineIBA 01/2018 - 05/2016
2	Carbon Tetrachloride (Tetrachloromethane)IBA 01/2018 - 11/2004
2	CytokinesIBA 05/2015 - 01/2015
1	KalininIBA 09/2023
1	Keratins (Keratin)IBA 09/2023
1	Protein Isoforms (Isoforms)IBA 07/2023
1	Heparin (Liquaemin)FDA LinkGeneric 01/2023
1	GlycosaminoglycansIBA 01/2023
1	AnticoagulantsIBA 01/2023
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2023
1	Uridine Diphosphate (UDP)IBA 11/2022
1	ectonucleotide pyrophosphatase phosphodiesterase 1IBA 08/2022
1	Interleukin-17 (Interleukin 17)IBA 01/2022
1	Tyrosine Kinase InhibitorsIBA 01/2022
1	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 01/2022
1	Anaplastic Lymphoma KinaseIBA 01/2022
1	ceritinibIBA 01/2022
1	Protein Kinase InhibitorsIBA 01/2022
1	Purinergic P2X4 ReceptorsIBA 01/2022

Therapy/Procedure

11	Therapeutics 09/2023 - 08/2008
7	Immunotherapy 01/2023 - 11/2018
2	Resistance Training 11/2023 - 12/2020
2	Ligation 12/2021 - 05/2016